Jerlhag explained more about the potential underlying mechanisms that the study found, noting: “We found that semaglutide prevents the reward from alcohol, and this might be the mechanism contributing to the reduced alcohol intake observed. Researchers note that, based on previous research, the effect of semaglutide would likely be similar among male mice. The male and female rats also experienced weight loss, which is a common effect of semaglutide.įurther research, including the use of male mice, looked at more of the underlying mechanisms that may be involved in this phenomenon, even though the mice were not used in the alcohol intake experiments that the rats were in. They abstain from alcohol, a white period, and then they start drinking more once they start. Relapse drinking is a huge problem in patients with AUD. Jerlhag explained: “We found that semaglutide prevents relapse drinking in both sexes. They found that semaglutide helped prevent relapse drinking. The researchers then looked at how the rats responded to the reintroduction of alcohol to see if they would return to their drinking baseline. They deprived the rats of alcohol for 9 days and then gave them semaglutide. Researchers further tested how semaglutide impacted drinking after a “sobriety” period. All rats have consumed alcohol for over 10 weeks before treatment, indicating that they are “addicted” to alcohol (as much as an animal can be).” This reduction is over half of what they drank before. “We found that semaglutide, given once or at several occasions, reduces alcohol intake in male and female rats. Elisabet Jerlhag, from the Department of Pharmacology at the Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, explained to Medical News Today: Rats that had received the medication exhibited reductions in their alcohol consumption. Then, when researchers gave the rats semaglutide, they measured its effects on alcohol consumption. They did this by providing alcohol 3 days per week. To start, they gave alcohol to a group of rats for about 9 weeks to establish a drinking habit. Researchers investigated how semaglutide affected the rats’ alcohol consumption. Researchers used mice and rats in their data collection. However, recent research has suggested the drug’s potential may be more diverse than just helping with diabetes treatment. Semaglutide is a medication that helps with the pancreas’ production of insulin.ĭoctors typically prescribe it to help some people with type 2 diabetes. This particular study looked at how semaglutide influenced drinking habits. Using a diabetes drug to lower alcohol use
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